Drug interactions
Amobarbital + Fentanyl transdermal
Severity: Major
Amobarbital and Fentanyl transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and opioids together cause additive CNS and respiratory depression, with risk of profound sedation, hypotension, coma and death. Amobarbital induction of CYP3A4 may lower fentanyl levels, and fentanyl toxicity can emerge when the inducer is withdrawn.
What this interaction means in plain words
Amobarbital and Fentanyl transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression plus CYP3A4 induction by amobarbital.
What to do
Use only if alternatives are inadequate, lowering doses where possible and monitoring sedation and respiration. Adjust patch dose when amobarbital is started or stopped, with monitoring for several days after changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Fentanyl transdermal?
MediHelp rates the interaction as major. Amobarbital and Fentanyl transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids together cause additive CNS and respiratory depression, with risk of profound sedation, hypotension, coma and death. Amobarbital induction of CYP3A4 may lower fentanyl levels, and fentanyl toxicity can emerge when the inducer is withdrawn.
How serious is the interaction between Amobarbital and Fentanyl transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, lowering doses where possible and monitoring sedation and respiration. Adjust patch dose when amobarbital is started or stopped, with monitoring for several days after changes.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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