Drug interactions
Amobarbital + Fosamprenavir
Severity: Moderate
Amobarbital and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital, a barbiturate, induces hepatic and intestinal CYP3A4 and may lower plasma concentrations of amprenavir, the active metabolite of fosamprenavir. This can reduce antiretroviral efficacy and promote virologic failure or resistance.
What this interaction means in plain words
Amobarbital and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases amprenavir metabolism.
What to do
Monitor HIV viral load and consider therapeutic drug monitoring of the protease inhibitor. Prefer a non-inducing sedative or anticonvulsant where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Fosamprenavir?
MediHelp rates the interaction as moderate. Amobarbital and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital, a barbiturate, induces hepatic and intestinal CYP3A4 and may lower plasma concentrations of amprenavir, the active metabolite of fosamprenavir. This can reduce antiretroviral efficacy and promote virologic failure or resistance.
How serious is the interaction between Amobarbital and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider therapeutic drug monitoring of the protease inhibitor. Prefer a non-inducing sedative or anticonvulsant where possible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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