Drug interactions
Amobarbital + Glecaprevir / pibrentasvir
Severity: Major
Amobarbital and Glecaprevir / pibrentasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and P-gp and may reduce glecaprevir and pibrentasvir exposure. This risks loss of antiviral activity and failure to achieve sustained virologic response.
What this interaction means in plain words
Amobarbital and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inducer-mediated increase in CYP3A4 and P-glycoprotein activity lowers drug concentrations.
What to do
Avoid coadministration; labeling advises against strong inducers, so use an alternative sedative or anticonvulsant during HCV therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as major. Amobarbital and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital induces CYP3A4 and P-gp and may reduce glecaprevir and pibrentasvir exposure. This risks loss of antiviral activity and failure to achieve sustained virologic response.
How serious is the interaction between Amobarbital and Glecaprevir / pibrentasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; labeling advises against strong inducers, so use an alternative sedative or anticonvulsant during HCV therapy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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