Drug interactions
Amobarbital + Griseofulvin
Severity: Moderate
Amobarbital and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower the effectiveness of oral griseofulvin. Treatment failure of the fungal infection may result.
What this interaction means in plain words
Amobarbital and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Griseofulvin belongs to Anti Fungals.
Why it happens
Barbiturates may reduce griseofulvin absorption and induce its hepatic metabolism.
What to do
Monitor clinical response to griseofulvin and consider a higher dose or an alternative antifungal if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Griseofulvin?
MediHelp rates the interaction as moderate. Amobarbital and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can lower the effectiveness of oral griseofulvin. Treatment failure of the fungal infection may result.
How serious is the interaction between Amobarbital and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to griseofulvin and consider a higher dose or an alternative antifungal if response is poor.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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