Drug interactions
Amobarbital + Hydrocortisone
Severity: Moderate
Amobarbital and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can increase the clearance of hydrocortisone, weakening its glucocorticoid effect. This matters in adrenal insufficiency, where under-replacement can lead to adrenal crisis.
What this interaction means in plain words
Amobarbital and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Amobarbital induces CYP3A4 and other hepatic enzymes, accelerating hydrocortisone metabolism.
What to do
Monitor clinical response and consider a higher hydrocortisone dose in adrenal insufficiency; reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Hydrocortisone?
MediHelp rates the interaction as moderate. Amobarbital and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can increase the clearance of hydrocortisone, weakening its glucocorticoid effect. This matters in adrenal insufficiency, where under-replacement can lead to adrenal crisis.
How serious is the interaction between Amobarbital and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider a higher hydrocortisone dose in adrenal insufficiency; reassess the dose when the barbiturate is stopped.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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