Drug interactions
Amobarbital + Ketamine
Severity: Moderate
Amobarbital and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and ketamine both produce CNS depression, so combined use can cause deeper sedation and respiratory or cardiovascular depression. Barbiturates may also prolong recovery from ketamine anesthesia.
What this interaction means in plain words
Amobarbital and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and NMDA antagonism.
What to do
Titrate each drug carefully and monitor respiration, oxygen saturation and hemodynamics, with airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Amobarbital with Ketamine?
MediHelp rates the interaction as moderate. Amobarbital and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and ketamine both produce CNS depression, so combined use can cause deeper sedation and respiratory or cardiovascular depression. Barbiturates may also prolong recovery from ketamine anesthesia.
How serious is the interaction between Amobarbital and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each drug carefully and monitor respiration, oxygen saturation and hemodynamics, with airway support available.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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