Drug interactions
Amobarbital + Lansoprazole
Severity: Minor
Amobarbital and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and may reduce lansoprazole exposure by speeding its metabolism. This could weaken acid suppression, although the clinical impact is not well characterized.
What this interaction means in plain words
Amobarbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C19 increases lansoprazole clearance.
What to do
Assess symptom control and increase the lansoprazole dose if acid suppression is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Lansoprazole?
MediHelp rates the interaction as minor. Amobarbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital is an enzyme inducer and may reduce lansoprazole exposure by speeding its metabolism. This could weaken acid suppression, although the clinical impact is not well characterized.
How serious is the interaction between Amobarbital and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess symptom control and increase the lansoprazole dose if acid suppression is inadequate.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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