Drug interactions
Amobarbital + Methoxyflurane
Severity: Contraindicated
Amobarbital and Methoxyflurane: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates such as amobarbital induce hepatic enzymes and can raise the biotransformation of methoxyflurane. This produces more inorganic fluoride and other nephrotoxic metabolites, increasing the risk of renal injury, including high-output renal failure.
What this interaction means in plain words
Amobarbital and Methoxyflurane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Barbiturate-mediated induction of hepatic CYP enzymes increases methoxyflurane metabolism to nephrotoxic fluoride-containing metabolites.
What to do
Avoid methoxyflurane in patients taking barbiturates and choose a different anesthetic or analgesic. If exposure has occurred, monitor renal function and urine output.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Methoxyflurane?
MediHelp rates the interaction as contraindicated. Amobarbital and Methoxyflurane are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates such as amobarbital induce hepatic enzymes and can raise the biotransformation of methoxyflurane. This produces more inorganic fluoride and other nephrotoxic metabolites, increasing the risk of renal injury, including high-output renal failure.
How serious is the interaction between Amobarbital and Methoxyflurane?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methoxyflurane in patients taking barbiturates and choose a different anesthetic or analgesic. If exposure has occurred, monitor renal function and urine output.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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