Drug interactions
Amobarbital + Metoclopramide intranasal
Severity: Moderate
Amobarbital and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause CNS depression, and metoclopramide can cause extrapyramidal and other neurologic effects. The combination may worsen somnolence and psychomotor impairment, though the exact interaction is poorly characterized.
What this interaction means in plain words
Amobarbital and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely additive CNS depressant effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for excessive sedation and movement disorders, and counsel patients about driving. Consider an alternative antiemetic if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Amobarbital and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause CNS depression, and metoclopramide can cause extrapyramidal and other neurologic effects. The combination may worsen somnolence and psychomotor impairment, though the exact interaction is poorly characterized.
How serious is the interaction between Amobarbital and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and movement disorders, and counsel patients about driving. Consider an alternative antiemetic if sedation is problematic.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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