Drug interactions
Amobarbital + Nitrendipine
Severity: Moderate
Amobarbital and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can reduce nitrendipine plasma concentrations because nitrendipine undergoes extensive CYP3A4 metabolism. Blood pressure control may be weakened.
What this interaction means in plain words
Amobarbital and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by amobarbital increases nitrendipine first-pass and systemic clearance.
What to do
Monitor blood pressure and increase the nitrendipine dose if needed, or use an antihypertensive not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Nitrendipine?
MediHelp rates the interaction as moderate. Amobarbital and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can reduce nitrendipine plasma concentrations because nitrendipine undergoes extensive CYP3A4 metabolism. Blood pressure control may be weakened.
How serious is the interaction between Amobarbital and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the nitrendipine dose if needed, or use an antihypertensive not dependent on CYP3A4.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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