Drug interactions
Amobarbital + Olanzapine
Severity: Moderate
Amobarbital and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and together may produce marked drowsiness and respiratory depression. Barbiturate enzyme induction may also lower olanzapine concentrations and weaken antipsychotic control.
What this interaction means in plain words
Amobarbital and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus induction of CYP1A2 and glucuronidation by amobarbital, increasing olanzapine clearance.
What to do
Monitor sedation, respiratory status and psychiatric symptoms. Increase the olanzapine dose if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Amobarbital with Olanzapine?
MediHelp rates the interaction as moderate. Amobarbital and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and together may produce marked drowsiness and respiratory depression. Barbiturate enzyme induction may also lower olanzapine concentrations and weaken antipsychotic control.
How serious is the interaction between Amobarbital and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status and psychiatric symptoms. Increase the olanzapine dose if efficacy is lost.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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