Drug interactions
Amobarbital + Ombitasvir / paritaprevir / ritonavir
Severity: Major
Amobarbital and Ombitasvir / paritaprevir / ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer that may lower paritaprevir and ritonavir levels, and possibly ombitasvir. This may lead to reduced antiviral activity, virologic failure and resistance.
What this interaction means in plain words
Amobarbital and Ombitasvir / paritaprevir / ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 increases the clearance of paritaprevir and ritonavir.
What to do
Avoid concurrent use and select a non-inducing sedative or anticonvulsant. Monitor HCV RNA response if exposure cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Ombitasvir / paritaprevir / ritonavir?
MediHelp rates the interaction as major. Amobarbital and Ombitasvir / paritaprevir / ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is an enzyme inducer that may lower paritaprevir and ritonavir levels, and possibly ombitasvir. This may lead to reduced antiviral activity, virologic failure and resistance.
How serious is the interaction between Amobarbital and Ombitasvir / paritaprevir / ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select a non-inducing sedative or anticonvulsant. Monitor HCV RNA response if exposure cannot be avoided.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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