Drug interactions
Amobarbital + Parecoxib
Severity: Minor
Amobarbital and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may induce enzymes involved in the metabolism of valdecoxib, the active metabolite of parecoxib, potentially lowering its exposure. The clinical effect is likely modest and may be reduced analgesia.
What this interaction means in plain words
Amobarbital and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction (CYP3A4 and CYP2C9) increases metabolism of valdecoxib.
What to do
Monitor analgesic response and adjust the dose within the labeled range if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Parecoxib?
MediHelp rates the interaction as minor. Amobarbital and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates may induce enzymes involved in the metabolism of valdecoxib, the active metabolite of parecoxib, potentially lowering its exposure. The clinical effect is likely modest and may be reduced analgesia.
How serious is the interaction between Amobarbital and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the dose within the labeled range if needed.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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