Drug interactions
Amobarbital + Pimozide
Severity: Moderate
Amobarbital and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS and together can cause excessive sedation. Barbiturate induction may also reduce pimozide exposure, and pimozide carries QT risk that complicates dose escalation.
What this interaction means in plain words
Amobarbital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 and CYP1A2 induction by amobarbital reducing pimozide levels.
What to do
Monitor sedation and clinical response, and avoid raising pimozide doses without ECG monitoring. Reassess dosing if amobarbital is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Amobarbital with Pimozide?
MediHelp rates the interaction as moderate. Amobarbital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS and together can cause excessive sedation. Barbiturate induction may also reduce pimozide exposure, and pimozide carries QT risk that complicates dose escalation.
How serious is the interaction between Amobarbital and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and clinical response, and avoid raising pimozide doses without ECG monitoring. Reassess dosing if amobarbital is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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