Drug interactions
Amobarbital + Progesterone micronized
Severity: Moderate
Amobarbital and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce CYP3A4 and may reduce circulating progesterone from oral micronized preparations, which undergo extensive first-pass metabolism. This may reduce endometrial protection in women on estrogen therapy or weaken luteal support.
What this interaction means in plain words
Amobarbital and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases progesterone metabolism.
What to do
Monitor for breakthrough bleeding or other signs of reduced progestogen effect. Adjust the progesterone dose or use a non-inducing alternative to amobarbital.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Progesterone micronized?
MediHelp rates the interaction as moderate. Amobarbital and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can induce CYP3A4 and may reduce circulating progesterone from oral micronized preparations, which undergo extensive first-pass metabolism. This may reduce endometrial protection in women on estrogen therapy or weaken luteal support.
How serious is the interaction between Amobarbital and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or other signs of reduced progestogen effect. Adjust the progesterone dose or use a non-inducing alternative to amobarbital.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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