Drug interactions
Amobarbital + Rifampin
Severity: Moderate
Amobarbital and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of hepatic enzymes and can increase amobarbital clearance, reducing its sedative or anticonvulsant effect. Dose requirements may rise during co-therapy and fall again after rifampin is stopped.
What this interaction means in plain words
Amobarbital and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces hepatic cytochrome P450 enzymes, accelerating barbiturate metabolism.
What to do
Monitor clinical response and adjust the amobarbital dose as needed. Reassess dosing when rifampin is started or discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Rifampin?
MediHelp rates the interaction as moderate. Amobarbital and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of hepatic enzymes and can increase amobarbital clearance, reducing its sedative or anticonvulsant effect. Dose requirements may rise during co-therapy and fall again after rifampin is stopped.
How serious is the interaction between Amobarbital and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adjust the amobarbital dose as needed. Reassess dosing when rifampin is started or discontinued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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