Drug interactions
Amobarbital + Selegiline transdermal
Severity: Minor
Amobarbital and Selegiline transdermal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been reported to prolong the effects of barbiturates, so increased sedation is possible. This is mainly theoretical for transdermal selegiline at low antidepressant doses.
What this interaction means in plain words
Amobarbital and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
MAO inhibition may reduce barbiturate metabolism, although the mechanism is not firmly established.
What to do
Monitor for excessive sedation and reduce the amobarbital dose if it develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Selegiline transdermal?
MediHelp rates the interaction as minor. Amobarbital and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors have been reported to prolong the effects of barbiturates, so increased sedation is possible. This is mainly theoretical for transdermal selegiline at low antidepressant doses.
How serious is the interaction between Amobarbital and Selegiline transdermal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the amobarbital dose if it develops.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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