Drug interactions
Amobarbital + Sildenafil
Severity: Moderate
Amobarbital and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and may reduce sildenafil concentrations, potentially causing loss of efficacy. Barbiturates can also add CNS depression.
What this interaction means in plain words
Amobarbital and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Sildenafil belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by amobarbital increases sildenafil metabolism.
What to do
Monitor erectile or pulmonary hypertension response and consider a higher sildenafil dose if efficacy is lost. In pulmonary arterial hypertension, watch for clinical worsening.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Sildenafil?
MediHelp rates the interaction as moderate. Amobarbital and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4 and may reduce sildenafil concentrations, potentially causing loss of efficacy. Barbiturates can also add CNS depression.
How serious is the interaction between Amobarbital and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor erectile or pulmonary hypertension response and consider a higher sildenafil dose if efficacy is lost. In pulmonary arterial hypertension, watch for clinical worsening.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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