Drug interactions
Amobarbital + Tezacaftor
Severity: Major
Amobarbital and Tezacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may markedly reduce tezacaftor concentrations through CYP3A induction. This could lead to loss of CFTR modulator efficacy.
What this interaction means in plain words
Amobarbital and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by amobarbital accelerates tezacaftor metabolism.
What to do
Avoid coadministration because labeling advises against strong CYP3A inducers. Use an alternative sedative and monitor respiratory outcomes if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Tezacaftor?
MediHelp rates the interaction as major. Amobarbital and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may markedly reduce tezacaftor concentrations through CYP3A induction. This could lead to loss of CFTR modulator efficacy.
How serious is the interaction between Amobarbital and Tezacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration because labeling advises against strong CYP3A inducers. Use an alternative sedative and monitor respiratory outcomes if exposure occurs.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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