Drug interactions
Amobarbital + Thiothixene
Severity: Moderate
Amobarbital and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combined use may cause excessive sedation and psychomotor impairment. Antipsychotics may also lower the seizure threshold, and barbiturates may alter antipsychotic levels through enzyme induction.
What this interaction means in plain words
Amobarbital and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible barbiturate-induced hepatic metabolism of the antipsychotic.
What to do
Monitor for oversedation and reduced antipsychotic effect, and adjust doses accordingly. Counsel patients regarding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Thiothixene?
MediHelp rates the interaction as moderate. Amobarbital and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combined use may cause excessive sedation and psychomotor impairment. Antipsychotics may also lower the seizure threshold, and barbiturates may alter antipsychotic levels through enzyme induction.
How serious is the interaction between Amobarbital and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduced antipsychotic effect, and adjust doses accordingly. Counsel patients regarding alcohol and driving.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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