Drug interactions
Amobarbital + Triazolam
Severity: Major
Amobarbital and Triazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs add to each other's CNS and respiratory depression, raising the risk of oversedation. Amobarbital may also induce CYP3A4 and reduce triazolam exposure, which can make the response unpredictable.
What this interaction means in plain words
Amobarbital and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A mediated CNS depression plus CYP3A4 induction by amobarbital.
What to do
Avoid combining where possible; if necessary use the lowest effective doses and monitor sedation and respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Triazolam?
MediHelp rates the interaction as major. Amobarbital and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The two drugs add to each other's CNS and respiratory depression, raising the risk of oversedation. Amobarbital may also induce CYP3A4 and reduce triazolam exposure, which can make the response unpredictable.
How serious is the interaction between Amobarbital and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary use the lowest effective doses and monitor sedation and respiratory status.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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