Drug interactions
Amobarbital + Zaleplon
Severity: Moderate
Amobarbital and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces hepatic enzymes including CYP3A4 and may lower zaleplon exposure, though aldehyde oxidase is the main metabolic route for zaleplon. Both drugs are sedative-hypnotics, so additive CNS and respiratory depression is the greater concern.
What this interaction means in plain words
Amobarbital and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depression, with barbiturate-mediated CYP3A4 induction modestly increasing zaleplon metabolism.
What to do
Avoid concurrent use of two hypnotics where possible. If used together, monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Zaleplon?
MediHelp rates the interaction as moderate. Amobarbital and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces hepatic enzymes including CYP3A4 and may lower zaleplon exposure, though aldehyde oxidase is the main metabolic route for zaleplon. Both drugs are sedative-hypnotics, so additive CNS and respiratory depression is the greater concern.
How serious is the interaction between Amobarbital and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two hypnotics where possible. If used together, monitor for oversedation and respiratory depression.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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