Drug interactions
Amobarbital + Zolpidem
Severity: Moderate
Amobarbital and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4, which may lower zolpidem concentrations and reduce its hypnotic effect. Both drugs are also sedatives, so pharmacodynamic additive CNS depression is a concern.
What this interaction means in plain words
Amobarbital and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
CYP3A4 induction by the barbiturate increases zolpidem metabolism, alongside additive GABA-A mediated CNS depression.
What to do
Avoid concurrent use of two sedative-hypnotics where possible. If used together, monitor for reduced hypnotic efficacy and for excess sedation, and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Zolpidem?
MediHelp rates the interaction as moderate. Amobarbital and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4, which may lower zolpidem concentrations and reduce its hypnotic effect. Both drugs are also sedatives, so pharmacodynamic additive CNS depression is a concern.
How serious is the interaction between Amobarbital and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two sedative-hypnotics where possible. If used together, monitor for reduced hypnotic efficacy and for excess sedation, and adjust doses accordingly.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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