Drug interactions
Amoxapine + Brexpiprazole
Severity: Moderate
Amoxapine and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with dopamine-blocking properties, and combining it with brexpiprazole increases sedation and the risk of orthostatic hypotension. Additive dopamine antagonism raises the risk of extrapyramidal symptoms and tardive dyskinesia, and amoxapine may also raise brexpiprazole exposure through CYP2D6 effects.
What this interaction means in plain words
Amoxapine and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and dopamine D2 blockade, with possible modest CYP2D6 inhibition by amoxapine increasing brexpiprazole levels.
What to do
Monitor sedation, blood pressure and movement disorders, and start at low doses. Watch for increased brexpiprazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Amoxapine with Brexpiprazole?
MediHelp rates the interaction as moderate. Amoxapine and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with dopamine-blocking properties, and combining it with brexpiprazole increases sedation and the risk of orthostatic hypotension. Additive dopamine antagonism raises the risk of extrapyramidal symptoms and tardive dyskinesia, and amoxapine may also raise brexpiprazole exposure through CYP2D6 effects.
How serious is the interaction between Amoxapine and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and movement disorders, and start at low doses. Watch for increased brexpiprazole adverse effects.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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