Drug interactions
Amoxapine + Bupropion-naltrexone
Severity: Major
Amoxapine and Bupropion-naltrexone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and can raise amoxapine concentrations, while both drugs lower the seizure threshold. The combination increases the risk of seizures and tricyclic-type adverse effects.
What this interaction means in plain words
Amoxapine and Bupropion-naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP2D6 inhibition by bupropion and its metabolites combined with additive seizure threshold lowering.
What to do
Avoid if possible; if combined, use low amoxapine doses and titrate slowly. Monitor for seizures, anticholinergic effects and cardiac toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Amoxapine with Bupropion-naltrexone?
MediHelp rates the interaction as major. Amoxapine and Bupropion-naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion inhibits CYP2D6 and can raise amoxapine concentrations, while both drugs lower the seizure threshold. The combination increases the risk of seizures and tricyclic-type adverse effects.
How serious is the interaction between Amoxapine and Bupropion-naltrexone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, use low amoxapine doses and titrate slowly. Monitor for seizures, anticholinergic effects and cardiac toxicity.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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