Drug reference
bupropion-naltrexone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Miscellaneous (Miscellaneous)
Mechanism of action
Bupropion: Increases dopamine activity in the brain, which appears to lead to a reduction in appetite and increase in energy expenditure by increasing activity of pro-opiomelanocortin (POMC) neurons Naltrexone: Blocks opioid receptors on the POMC neurons, preventing feedback inhibition of these neurons and further increasing POMC activity.
Common side effects
- Insomnia
- Constipation
- Dizziness
- Vomiting
- Hot flashes
- Anxiety
- Headaches
- Dry Mouth
- nausea
Related conditions
Frequently asked questions
What drug class is bupropion-naltrexone?
bupropion-naltrexone belongs to: Miscellaneous.
How does bupropion-naltrexone work?
Bupropion: Increases dopamine activity in the brain, which appears to lead to a reduction in appetite and increase in energy expenditure by increasing activity of pro-opiomelanocortin (POMC) neurons Naltrexone: Blocks opioid receptors on the POMC neurons, preventing feedback inhibition of these neurons and further increasing POMC activity.
What are the common side effects of bupropion-naltrexone?
Insomnia, Constipation, Dizziness, Vomiting, Hot flashes, Anxiety, Headaches, Dry Mouth, nausea
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