Drug interactions
Bupropion-naltrexone + Hydromorphone
Severity: Contraindicated
Bupropion-naltrexone and Hydromorphone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
What this interaction means in plain words
Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydromorphone belongs to Musculoskeletal.
Why it happens
Naltrexone competitively antagonizes mu opioid receptors, opposing hydromorphone effects.
What to do
Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion-naltrexone + Selegiline Contraindicated
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
- Alfentanil + Hydromorphone Major
Frequently asked questions
Can I take Bupropion-naltrexone with Hydromorphone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
How serious is the interaction between Bupropion-naltrexone and Hydromorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
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