Drug interactions
Amoxapine + Carbamazepine
Severity: Moderate
Amoxapine and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower amoxapine concentrations and weaken antidepressant effect. Both drugs share tricyclic-like structures and can have additive anticholinergic or cardiac effects.
What this interaction means in plain words
Amoxapine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbamazepine induces hepatic CYP enzymes, increasing amoxapine clearance.
What to do
Monitor depressive symptoms and consider amoxapine dose increase if response diminishes. Reassess dose if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amoxapine with Carbamazepine?
MediHelp rates the interaction as moderate. Amoxapine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower amoxapine concentrations and weaken antidepressant effect. Both drugs share tricyclic-like structures and can have additive anticholinergic or cardiac effects.
How serious is the interaction between Amoxapine and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and consider amoxapine dose increase if response diminishes. Reassess dose if carbamazepine is stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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