Drug interactions
Amoxapine + Clorazepate
Severity: Moderate
Amoxapine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with antihistaminic and anticholinergic effects. Together with clorazepate it can increase drowsiness, impaired psychomotor performance and fall risk.
What this interaction means in plain words
Amoxapine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedating receptor-blocking actions of amoxapine.
What to do
Monitor for oversedation and impaired coordination, particularly in older patients, and use lower starting doses. Advise avoiding alcohol and caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Amoxapine with Clorazepate?
MediHelp rates the interaction as moderate. Amoxapine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with antihistaminic and anticholinergic effects. Together with clorazepate it can increase drowsiness, impaired psychomotor performance and fall risk.
How serious is the interaction between Amoxapine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired coordination, particularly in older patients, and use lower starting doses. Advise avoiding alcohol and caution with driving.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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