Drug interactions
Amoxapine + Desflurane
Severity: Moderate
Amoxapine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating tricyclic-type antidepressant with anticholinergic and alpha-blocking effects. With desflurane it may increase sedation, cause hypotension and contribute to arrhythmias. Amoxapine can also lower the seizure threshold.
What this interaction means in plain words
Amoxapine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and cardiovascular effects from antihistaminic, anticholinergic and alpha-adrenergic blockade.
What to do
Titrate desflurane to effect and monitor ECG, blood pressure and depth of anesthesia. Have a direct-acting vasopressor available for hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Amoxapine with Desflurane?
MediHelp rates the interaction as moderate. Amoxapine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating tricyclic-type antidepressant with anticholinergic and alpha-blocking effects. With desflurane it may increase sedation, cause hypotension and contribute to arrhythmias. Amoxapine can also lower the seizure threshold.
How serious is the interaction between Amoxapine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to effect and monitor ECG, blood pressure and depth of anesthesia. Have a direct-acting vasopressor available for hypotension.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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