Drug interactions
Amoxapine + Ethinyl estradiol-drospirenone
Severity: Minor
Amoxapine and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may raise tricyclic antidepressant concentrations in some patients, increasing anticholinergic, sedative and cardiovascular adverse effects. Antidepressant response may also be altered, although the effect is inconsistent.
What this interaction means in plain words
Amoxapine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed inhibition of hepatic oxidative metabolism of tricyclics by estrogens; the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia after starting the contraceptive. Reduce the amoxapine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Amoxapine with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Amoxapine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may raise tricyclic antidepressant concentrations in some patients, increasing anticholinergic, sedative and cardiovascular adverse effects. Antidepressant response may also be altered, although the effect is inconsistent.
How serious is the interaction between Amoxapine and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as sedation, dry mouth and tachycardia after starting the contraceptive. Reduce the amoxapine dose if toxicity appears.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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