Drug interactions
Amoxapine + Granisetron
Severity: Moderate
Amoxapine and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity and serotonin syndrome has been reported with 5-HT3 antagonists combined with antidepressants. Amoxapine may also prolong the QT interval, and granisetron adds a small effect.
What this interaction means in plain words
Amoxapine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect and minor additive QT prolongation; the mechanisms are not firmly established.
What to do
Monitor for agitation, tremor, clonus, sweating and hyperthermia after starting granisetron. Stop the agents and give supportive care if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Frequently asked questions
Can I take Amoxapine with Granisetron?
MediHelp rates the interaction as moderate. Amoxapine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity and serotonin syndrome has been reported with 5-HT3 antagonists combined with antidepressants. Amoxapine may also prolong the QT interval, and granisetron adds a small effect.
How serious is the interaction between Amoxapine and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, sweating and hyperthermia after starting granisetron. Stop the agents and give supportive care if serotonin syndrome occurs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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