Drug interactions
Apomorphine + Granisetron
Severity: Contraindicated
Apomorphine and Granisetron: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
What this interaction means in plain words
Apomorphine and Granisetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Mechanism is not established.
What to do
Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Granisetron
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
- Apomorphine + Palonosetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Granisetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Granisetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
How serious is the interaction between Apomorphine and Granisetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Granisetron page.
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