Drug interactions
Arsenic trioxide + Granisetron
Severity: Major
Arsenic trioxide and Granisetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide has a boxed warning for QT prolongation, torsades de pointes and complete AV block. Granisetron can also lengthen the QT interval, so the combination increases arrhythmia risk.
What this interaction means in plain words
Arsenic trioxide and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid other QT-prolonging drugs where possible and consider an antiemetic with less QT effect. If granisetron is needed, correct potassium and magnesium and monitor ECG throughout arsenic trioxide therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
- Asenapine transdermal + Granisetron Major
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Granisetron?
MediHelp rates the interaction as major. Arsenic trioxide and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide has a boxed warning for QT prolongation, torsades de pointes and complete AV block. Granisetron can also lengthen the QT interval, so the combination increases arrhythmia risk.
How serious is the interaction between Arsenic trioxide and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid other QT-prolonging drugs where possible and consider an antiemetic with less QT effect. If granisetron is needed, correct potassium and magnesium and monitor ECG throughout arsenic trioxide therapy.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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