Drug interactions
Amoxapine + Hydroxyzine
Severity: Moderate
Amoxapine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so the combination can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Both can also prolong the QT interval, which is a concern in patients with other risk factors.
What this interaction means in plain words
Amoxapine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, antimuscarinic effects and QT prolongation.
What to do
Use the lowest effective doses and monitor sedation and anticholinergic effects, especially in older adults. Consider an ECG and electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Amoxapine with Hydroxyzine?
MediHelp rates the interaction as moderate. Amoxapine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so the combination can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion. Both can also prolong the QT interval, which is a concern in patients with other risk factors.
How serious is the interaction between Amoxapine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and anticholinergic effects, especially in older adults. Consider an ECG and electrolytes in patients with cardiac risk factors.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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