Drug interactions
Amoxapine + Indacaterol-glycopyrronium
Severity: Moderate
Amoxapine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a tricyclic antidepressant with anticholinergic activity and QT-prolonging potential. Combined with the glycopyrronium component, anticholinergic effects such as dry mouth, urinary retention and constipation may be additive. Tricyclic agents also potentiate the cardiovascular effects of beta2-agonists such as indacaterol, raising the risk of ventricular arrhythmias.
What this interaction means in plain words
Amoxapine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, plus additive QT prolongation and potentiation of beta2-agonist cardiovascular effects by tricyclic antidepressants.
What to do
Monitor ECG and heart rate, particularly in patients with cardiac disease or electrolyte disturbances. Watch for urinary retention, constipation, glaucoma symptoms and other anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Amoxapine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Amoxapine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a tricyclic antidepressant with anticholinergic activity and QT-prolonging potential. Combined with the glycopyrronium component, anticholinergic effects such as dry mouth, urinary retention and constipation may be additive. Tricyclic agents also potentiate the cardiovascular effects of beta2-agonists such as indacaterol, raising the risk of ventricular arrhythmias.
How serious is the interaction between Amoxapine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, particularly in patients with cardiac disease or electrolyte disturbances. Watch for urinary retention, constipation, glaucoma symptoms and other anticholinergic effects.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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