Drug interactions
Clomipramine + Indacaterol-glycopyrronium
Severity: Major
Clomipramine and Indacaterol-glycopyrronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Clomipramine is also strongly anticholinergic, adding to glycopyrronium's antimuscarinic effects.
What this interaction means in plain words
Clomipramine and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, enhanced adrenergic cardiac effects and additive antimuscarinic activity.
What to do
Obtain a baseline ECG and monitor QTc, heart rate and electrolytes. Watch for anticholinergic effects such as urinary retention and constipation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Clomipramine and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. Clomipramine is also strongly anticholinergic, adding to glycopyrronium's antimuscarinic effects.
How serious is the interaction between Clomipramine and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate and electrolytes. Watch for anticholinergic effects such as urinary retention and constipation.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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