Drug interactions
Arsenic trioxide + Indacaterol-glycopyrronium
Severity: Major
Arsenic trioxide and Indacaterol-glycopyrronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Adding indacaterol, which can influence repolarization, heart rate and potassium levels, may add to the arrhythmic risk.
What this interaction means in plain words
Arsenic trioxide and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta2-agonist induced hypokalemia worsening arrhythmia susceptibility.
What to do
Prefer alternative bronchodilators during arsenic trioxide therapy if feasible. If combined, keep potassium and magnesium replete and monitor ECG regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Arsenic trioxide and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Adding indacaterol, which can influence repolarization, heart rate and potassium levels, may add to the arrhythmic risk.
How serious is the interaction between Arsenic trioxide and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer alternative bronchodilators during arsenic trioxide therapy if feasible. If combined, keep potassium and magnesium replete and monitor ECG regularly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Betaxolol. The full list is on the Indacaterol-glycopyrronium page.
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