Drug interactions
Amoxapine + Midazolam
Severity: Moderate
Amoxapine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with antipsychotic-like properties. Together with midazolam, CNS depression and psychomotor impairment are additive.
What this interaction means in plain words
Amoxapine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and amoxapine antihistaminic and anticholinergic effects.
What to do
Use reduced midazolam doses and monitor sedation level and respiratory status. Counsel ambulatory patients about impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Amoxapine with Midazolam?
MediHelp rates the interaction as moderate. Amoxapine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with antipsychotic-like properties. Together with midazolam, CNS depression and psychomotor impairment are additive.
How serious is the interaction between Amoxapine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced midazolam doses and monitor sedation level and respiratory status. Counsel ambulatory patients about impaired driving.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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