Drug interactions
Amoxapine + Mirabegron
Severity: Moderate
Amoxapine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and may raise concentrations of CYP2D6 substrates such as amoxapine. Higher levels could increase anticholinergic, sedative and cardiac adverse effects.
What this interaction means in plain words
Amoxapine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mirabegron inhibits CYP2D6, reducing amoxapine metabolism.
What to do
Monitor for tricyclic adverse effects and consider a lower amoxapine dose when mirabegron is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Atomoxetine + Mirabegron Moderate
Frequently asked questions
Can I take Amoxapine with Mirabegron?
MediHelp rates the interaction as moderate. Amoxapine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate CYP2D6 inhibitor and may raise concentrations of CYP2D6 substrates such as amoxapine. Higher levels could increase anticholinergic, sedative and cardiac adverse effects.
How serious is the interaction between Amoxapine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider a lower amoxapine dose when mirabegron is started.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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