Drug interactions
Atomoxetine + Mirabegron
Severity: Moderate
Atomoxetine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine is mainly cleared by CYP2D6, so mirabegron's inhibition may raise its levels. This may increase heart rate, blood pressure and other adverse effects, and mirabegron itself can raise blood pressure.
What this interaction means in plain words
Atomoxetine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Moderate CYP2D6 inhibition by mirabegron reduces atomoxetine clearance.
What to do
Monitor heart rate and blood pressure and watch for atomoxetine adverse effects. Reduce the atomoxetine dose if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Mirabegron?
MediHelp rates the interaction as moderate. Atomoxetine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine is mainly cleared by CYP2D6, so mirabegron's inhibition may raise its levels. This may increase heart rate, blood pressure and other adverse effects, and mirabegron itself can raise blood pressure.
How serious is the interaction between Atomoxetine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and watch for atomoxetine adverse effects. Reduce the atomoxetine dose if tolerability is poor.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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