Drug interactions
Amitriptyline + Mirabegron
Severity: Moderate
Amitriptyline and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates such as amitriptyline. This may increase anticholinergic, sedative and cardiac effects, especially with a narrow margin of safety.
What this interaction means in plain words
Amitriptyline and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6 by mirabegron reduces metabolism of amitriptyline.
What to do
Monitor for tricyclic adverse effects, including anticholinergic effects, sedation and arrhythmia. Lower the amitriptyline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amoxapine + Mirabegron Moderate
- Atomoxetine + Mirabegron Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Mirabegron?
MediHelp rates the interaction as moderate. Amitriptyline and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates such as amitriptyline. This may increase anticholinergic, sedative and cardiac effects, especially with a narrow margin of safety.
How serious is the interaction between Amitriptyline and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects, including anticholinergic effects, sedation and arrhythmia. Lower the amitriptyline dose if needed.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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