Drug interactions
Mirabegron + Propafenone
Severity: Major
Mirabegron and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is metabolised by CYP2D6 and has a narrow therapeutic index, so mirabegron may increase its levels. This raises the risk of proarrhythmia, conduction slowing and CNS adverse effects.
What this interaction means in plain words
Mirabegron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mirabegron belongs to Genitourinary; Propafenone belongs to Cardiovascular.
Why it happens
Mirabegron inhibits CYP2D6, reducing propafenone clearance.
What to do
Monitor ECG and clinical response when combining, and reduce the propafenone dose if QRS widening or other toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
- Atomoxetine + Mirabegron Moderate
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Mirabegron with Propafenone?
MediHelp rates the interaction as major. Mirabegron and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propafenone is metabolised by CYP2D6 and has a narrow therapeutic index, so mirabegron may increase its levels. This raises the risk of proarrhythmia, conduction slowing and CNS adverse effects.
How serious is the interaction between Mirabegron and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and clinical response when combining, and reduce the propafenone dose if QRS widening or other toxicity occurs.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Thioridazine. The full list is on the Mirabegron page.
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