Drug interactions
Amoxapine + Moxifloxacin
Severity: Major
Amoxapine and Moxifloxacin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and amoxapine may also cause tachycardia and conduction effects in overdose. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Amoxapine and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use a non-QT-prolonging antibiotic if possible. If the combination is needed, check ECG and electrolytes and monitor QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Avelox 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: tricyclic antidepressive agents; "tricyclic antidepressive agents") — electronic medicines compendium (UK SmPC)
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Amoxapine with Moxifloxacin?
MediHelp rates the interaction as major. Amoxapine and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and amoxapine may also cause tachycardia and conduction effects in overdose. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Amoxapine and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic if possible. If the combination is needed, check ECG and electrolytes and monitor QTc.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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