Drug interactions
Amoxapine + Nabilone
Severity: Moderate
Amoxapine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and cannabinoids can also cause tachycardia and additive anticholinergic-like or hypotensive effects with tricyclic-type antidepressants. Together they may impair alertness and cause dizziness or rapid heart rate.
What this interaction means in plain words
Amoxapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and cardiovascular effects.
What to do
Start nabilone at a low dose and monitor sedation, heart rate and blood pressure; counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Amoxapine with Nabilone?
MediHelp rates the interaction as moderate. Amoxapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and cannabinoids can also cause tachycardia and additive anticholinergic-like or hypotensive effects with tricyclic-type antidepressants. Together they may impair alertness and cause dizziness or rapid heart rate.
How serious is the interaction between Amoxapine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nabilone at a low dose and monitor sedation, heart rate and blood pressure; counsel against driving.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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