Drug interactions
Amoxapine + Saxagliptin
Severity: Minor
Amoxapine and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants can alter glucose regulation, and an additive glucose-lowering effect with saxagliptin has been suggested. The clinical effect is generally small.
What this interaction means in plain words
Amoxapine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic effect on glucose homeostasis; the mechanism is not well established.
What to do
Monitor blood glucose when amoxapine is started or stopped. Adjust antidiabetic therapy only if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amoxapine and Saxagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Amoxapine with Saxagliptin?
MediHelp rates the interaction as minor. Amoxapine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic-type antidepressants can alter glucose regulation, and an additive glucose-lowering effect with saxagliptin has been suggested. The clinical effect is generally small.
How serious is the interaction between Amoxapine and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when amoxapine is started or stopped. Adjust antidiabetic therapy only if glucose changes.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
