Drug interactions
Amlodipine-benazepril + Saxagliptin
Severity: Moderate
Amlodipine-benazepril and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and DPP-4 inhibitors have been associated with angioedema, and using them together may raise that risk. Patients should be aware of swelling of the face, lips or tongue.
What this interaction means in plain words
Amlodipine-benazepril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Both drugs reduce degradation of vasoactive peptides such as substance P and bradykinin, which may promote angioedema.
What to do
Counsel patients to seek urgent care for swelling of the face, lips or throat, and stop the suspected drug if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
- Butabarbital + Saxagliptin Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Saxagliptin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and DPP-4 inhibitors have been associated with angioedema, and using them together may raise that risk. Patients should be aware of swelling of the face, lips or tongue.
How serious is the interaction between Amlodipine-benazepril and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the face, lips or throat, and stop the suspected drug if angioedema occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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