Drug interactions
Aripiprazole + Saxagliptin
Severity: Moderate
Aripiprazole and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole may raise blood glucose in some patients, which can reduce the effect of saxagliptin. Glycemic control may need reassessment.
What this interaction means in plain words
Aripiprazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as atypical antipsychotics can impair glucose regulation.
What to do
Monitor blood glucose and HbA1c after starting aripiprazole. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
- Butabarbital + Saxagliptin Moderate
Frequently asked questions
Can I take Aripiprazole with Saxagliptin?
MediHelp rates the interaction as moderate. Aripiprazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole may raise blood glucose in some patients, which can reduce the effect of saxagliptin. Glycemic control may need reassessment.
How serious is the interaction between Aripiprazole and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting aripiprazole. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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