Drug interactions
Benazepril + Saxagliptin
Severity: Moderate
Benazepril and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors have been associated with an increased incidence of angioedema in patients taking ACE inhibitors. Both drugs reduce breakdown of peptides such as bradykinin and substance P.
What this interaction means in plain words
Benazepril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Reduced degradation of bradykinin and substance P through combined ACE and DPP-4 inhibition.
What to do
Counsel patients to report swelling of the face, lips, tongue, or throat immediately. Discontinue the suspected agent and treat angioedema if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Butabarbital + Saxagliptin Moderate
Frequently asked questions
Can I take Benazepril with Saxagliptin?
MediHelp rates the interaction as moderate. Benazepril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors have been associated with an increased incidence of angioedema in patients taking ACE inhibitors. Both drugs reduce breakdown of peptides such as bradykinin and substance P.
How serious is the interaction between Benazepril and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips, tongue, or throat immediately. Discontinue the suspected agent and treat angioedema if it occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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