Drug interactions
Amphotericin b + Benazepril
Severity: Moderate
Amphotericin b and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B can cause infusion-related hypotension, volume depletion and renal impairment, and ACE inhibitors lower blood pressure and reduce renal perfusion pressure. Together they may cause more hypotension and acute kidney injury.
What this interaction means in plain words
Amphotericin b and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Benazepril belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering and combined renal hemodynamic effects with amphotericin nephrotoxicity.
What to do
Monitor blood pressure, serum creatinine and potassium during amphotericin therapy. Consider temporarily holding benazepril if hypotension or renal function decline develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Amphotericin b with Benazepril?
MediHelp rates the interaction as moderate. Amphotericin b and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause infusion-related hypotension, volume depletion and renal impairment, and ACE inhibitors lower blood pressure and reduce renal perfusion pressure. Together they may cause more hypotension and acute kidney injury.
How serious is the interaction between Amphotericin b and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium during amphotericin therapy. Consider temporarily holding benazepril if hypotension or renal function decline develops.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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